Genetic Disorders – Old Year Questions

1. Which one of the following is not an genetic disease?

(a) Night blindness
(b) Albinism
(c) Haemophilia
(d) Colour blindness

[U.P.P.C.S. (Pre) 2017]


2. Phenylketonuria is an example of an inborn error of metabolism. This ‘error’ refers to :

(a) hormonal overproduction
(b) atrophy of endocrine glands
(c) inherited lack of an enzyme
(d) non-disjunction

[I.A.S. (Pre) 1994]


3. A person affected by phenylketonuria disease suffers from :

(a) Kidney failure
(b) Liver failure
(c) Mental idiocy
(d) Impotence

[R.A.S./R.T.S.(Pre) 1999]


4. The famous ‘Bubble Baby Disease’ is so called because :

(a) It is caused by water bubble
(b) The suffering baby makes bubbles of saliva
(c) The suffering baby is treated in a germ-free plastic bubble
(d) It is cured only water bubble

[U.P.P.C.S. (Pre) 1997]


5. Haemophilia is a genetic disease carried by –

(a) Women appear in women
(b) Women, appear in men
(c) Men appear in women
(d) Men appear in men

[I.A.S. (Pre) 1993]


6. Haemophilia is :

(a) Caused by bacteria
(b) Caused by virus
(c) Caused by pollutants
(d) A hereditary defect

[U.P. Lower Sub. (Pre) 2015]


7. Which one of the following genetic diseases is sex-linked?

(a) Royal haemophilia
(b) Tay-Sachs disease
(c) Cystic fibrosis
(d) Hypertension

[U.P.P.C.S. (Spl.) (Pre) 2008]

[I.A.S. (Pre) 1999]


8. Haemophilia is a hereditary disease which affects as –

(a) Lack of Hb
(b) Rheumatoid leant disease
(c) Lack in WBC
(d) Absence of blood clotting

[U.P.P.C.S. (Pre) 2003]


9. The heritable disease is :

(a) Haemophilia
(b) T.B.
(c) Cancer
(d) Jaundice

[U.P.P.C.S. (Mains) 2007]
[Uttarakhand P.C.S. (Pre) 2006]


10. Which of the following is not a genetic disorder?

(a) Down-syndrome
(b) Haemophilia
(c) Irritable Bowel Syndrome (IBS)
(d) Sickle Cell Anaemia

[Uttarakhand P.C.S. (Pre) 2010]


11. In humans trisomy of chromosome number 21 is responsible for :

(a) Haemophilia
(b) Klinefelter Syndrome
(c) Down Syndrome
(d) Turner Syndrome

[R.A.S/R.T.S (Pre) 2018]


12. Trisomy 21 is known as :

(a) Evans syndrome
(b) Edwards syndrome
(c) Down syndrome
(d) Gray baby syndrome

[R.A.S./ R.T.S. (Pre) 2021]


13. Down syndrome is a genetic disorder, which is caused due to –

(a) Due to changes in the number of the chromosomes
(b) Due to changes in the structure of the chromosome
(c) Due to changes in the structure of D.N.A.
(d) Due to changes in the structure of R.N.A.

[R.A.S./R.T.S. (Pre) 1999]


14. Which one of the following is caused by the expression of a recessive gene present on sex chromosome ?

(a) Rheumatism
(b) Nervous shock
(c) Muscular dystrophy
(d) Cerebral hemorrhage

[I.A.S. (Pre) 1994]

15. Match List-I (Disease) with List-II (Types of disease)
and select the correct answer using the codes given below :
List-I List-II
A. Haemophilia 1. Deficiency disease
B. Diabetes 2. Genetic disease
C. Rickets 3. Hormonal disorder
D. Ringworm 4. Fungal infection

Code :
(a) 2 3 4 1
(b) 2 3 1 4
(c) 3 2 1 4
(d) 3 2 4 1

[I.A.S. (Pre) 2000]

16. Which one of the following sets is correctly matched ?

(a) Diphtheria, Pneumonia – Sex-linked and Leprosy
(b) AIDS, Syphilis and – Bacterial Gonorrhoea
(c) Colour blindness, – Hereditary Haemophilia and Sickle cell anaemia
(d) Polio, Japanese B – Viral encephalitis and Plague

[I.A.S. (Pre) 1995]


17. In respect of women, men can suffer more of colour blindness because-

(a) They pass more through mental tensions
(b) They live out of home relatively more
(c) They have only one X-chromosome
(d) Commonly they have less fat

[41st B.P.S.C. (Pre) 1996]


18. Which one of the following pairs is incorrectly matched?

(a) Thiamine – Beriberi
(b) Ascorbic acid – Scurvy
(c) Vitamin A – Colour blindness
(d) Vitamin K – Blood clotting

U.P. P.C.S. (Pre) 2016


19. If a colour blind man marries with normal women, then the symptoms of colour blindness is generated in :

(a) Sons
(b) Daughters
(c) Sons of sons
(d) Sons of daughters

[U.P.P.C.S. (Pre) 2009]


20. A colour blind person (man) get married to a normal woman whose parents were not colour blind.
The possibility of being colour blind in their children is –

(a) 25%
(b) 50%
(c) 100%
(d) 0%

[Uttarakhand U.D.A./L.D.A. (Pre) 2003]


21. In the context of genetic disorders, consider the following :
A woman suffers from colour blindness while her husband does not suffer from it. They have a son and a daughter. In this context, which one of the following statements is most probably correct?

(a) Both children suffers from colour blindness
(b) Daughter suffers from colour blindness while son does not suffer from it
(c) Both children do not suffer from colour blindness
(d) Son suffers from colour blindness while daughter does not suffer from it

[I.A.S. (Pre) 2009]


22. In a patient of Thalassemia, the body is unable to synthesise –

(a) Vitamin D
(b) Hormones
(c) Haemoglobin
(d) Protein

[Uttarakhand P.C.S. (Pre) 2005]


23. Thalassemia is a hereditary disease which affects

(a) Blood
(b) Lungs
(c) Heart
(d) Kidney

[Uttarakhand P.C.S. (Pre) 2016]
[Jharkhand P.C.S. (Pre) 2013]